The Panama-Pacific International Exposition Collection contains materials related to the 1915 Panama-Pacific International Exposition which was located in San Francisco. This collection, which dates from 1915 through 1916, contains souvenir brochures, guides and pamphlets and a bound paper titled "The illumination of the Panama-Pacific International Exposition."

The Postcard Collection, which spans from 1920 through 1920, contains postcards from all fifty states, as well as France, Germany, and other countries.

The Railroads Collection contains materials related to railroads operating in the Northwest region of the United States.

The San Francisco Photographs contains materials related to the city of San Francisco, California before and after the earthquake and fire of 1906. This collection, which dates from 1905 through 1906, also consists of postcards and souvenir booklets.

The Samuel M. Stout Journal, which dates from circa 1851, houses a typed and photocopied version of Samuel M. Stout's journal.

The Texts, Lecturers, and Historical Writings Collection, which dates from 1888 through 1946, contains materials related to the instruction of writing and drawing, the description of an individual, the history of a medical college and a lecture on "good cheer."

The Listeners Project: Queremos Escucharte is a place based project promoting listening as a tool for building community, empowering one another, and celebrating our lives. The project records and shares stories from communities who have been historically left out, lost, or misrepresented in narratives about Walla Walla, Washington.

The Walla Walla Arts Ephemera Collection contains a range of memorabilia from Walla Walla, Washington artistic events.

The Walla Walla Bank Collection consists of materials related to banking institutions in Walla Walla, Washington including stock certificates, calendars, annual reports, anniversary publications, newspaper clippings, correspondence, and bank drafts.

The Walla Walla Health Services Collection date from 1919 through 2000. It contains memoranda, statistical reports, bulletins, newspaper clippings, and letters from Planned Parenthood, Christian Aid Rescue Mission, and Washington Tuberculosis Association located in Walla Walla, Washington.